Broccoli could combat prostate cancer, finds study

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A novel study highlights the benefits of consuming broccoli, saying that it might reduce the odds of abnormal cells that divide without control, which can invade nearby tissues or spread through the bloodstream and lymphatic system to other parts of the body.

Researchers from Institute of Food Research, at Norwich Research Park, UK, found a chemical called sulforaphane in broccoli to have properties that fight prostate cancer [abnormal cells that divide without control, which can invade nearby tissues or spread through the bloodstream and lymphatic system to other parts of the body. ] .

WebMD quoted Dr. Kate Holmes, research manager at The Prostate Cancer Charity, UK as saying, “The role of a healthy diet in the development and growth of prostate cancer
has been a focus of research attention for many years.”

Researchers conducted experiments on human prostate tissue and prostate cancer from mice to understand the gene that causes prostate cancer.

They also aimed at understanding the functioning of the cancer fighting chemical sulforaphane.

According to researchers, sulforaphane works together with cells lacking a key anti-tumour gene PTEN to fight against prostate cancer.

“PTEN is a tumour suppressor gene, the deletion or inactivation of which can initiate prostate carcinogenesis, and enhance the probability of cancer progression,” study-leader Professor Richard Mithen was quoted by WebMD as saying.

Study showed that sulforaphane acted differently depending on the presence or absence of PTEN gene.

It thus found that sulphoraphane did not affect cancer growth in cells with normally functioning PTEN.

However, it caused the tumour cells with defective PTEN gene to become less aggressive along with enhancing their survival.

Study conclusions
Emphasizing on curative properties of broccoli (sulforaphane), researchers stated, “This may explain how diets rich in broccoli, the dietary source of sulforaphane, can reduce the risk of incidence of prostate cancer and the progression of localised prostate cancer to more aggressive forms of this disease.”

Underlining the importance of further research, scientists were quoted by WebMD as saying, “Whilst it is difficult to draw any firm conclusions, the results of this study do suggest that there is merit in further research into the role of sulforaphane, both in relation to its impact on men already diagnosed with prostate cancer and in the prevention of the disease, as was investigated in this instance.”

Stressing on lifestyle changes, WebMD quoted Holmes as saying, “Moving away from a diet rich in meat and saturated fat will improve overall health and reduce the risk of chronic conditions like heart disease as well as possibly helping to prevent prostate cancer.”

“A diet rich in fruit and vegetables combined with a physically active lifestyle gives you the best chance of protecting your long-term health,” added Holmes.

The research appears online in the journal Molecular Cancer.


source:  http://www.themedguru.com/20100714/newsfeature/broccoli-could-combat-prostate-cancer-finds-study-86137322.html

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